SupaClean™ for Pharmaceutical Applications

Safe and Efficient Catalyst Recovery, Decolourisation and particulate / precipitate removal in chemically synthesised API manufacturing. 

Overview

As API's manufactured through chemical synthesis increase in potency year on year, the need to protect your operators becomes a significant part selecting the most appropriate filtration and separation solution.  SupaClean™ is a versatile fully contained filtration system, ideal for limiting operator exposure when processing potent HP-API starter materials , intermediates and final product.  Protecting Your People , Your Product, Your Process. The SupaClean can accommodate any filter within our portfolio making it customisable for a variety of applications.

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Capture, Recover and Reprocess Valuable Catalyst

Our customised design of SupaClean™ has the capacity to capture up to 10kg of catalyst. Mounting in parallel can expand capacity as desired. The contained design also aids safer handling by the re-processor.

Metals such as Palladium and Rhodium should always be recovered wherever possible. This lowers environmental impact while the pharmaceutical manufacturer can realise substantial payback on the recovered metal reprocessed.

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Precipitate and General Particulate Removal

Whether it is filtering precursor solvents or removing precipitates formed during reactor chemical synthesis, the SupaClean™ system protects your personnel and your process.

Depending on the efficiency,  batch volume or flowrate we can install our full range of filters into the SupaClean™ system. These include Meltblown depth, Pleated depth and our range of microbially retentive membrane filters. 

simplify-your-decolourisation-process

Simplify and Improve Your Decolourisation and Solvent Recovery Process

You need a colour reduction process that is both swift and effective. Our Carbon Block systems offer a high surface area of active carbon in the convenience of a cartridge.

The SupaCarb CP provides superior colour reduction while minimising waste and eliminating operator exposure when teamed with the SupaClean™ system.

Simplify Operations and Improve Health and Safety throughout your API Manufacturing

SupaClean™ systems for Pharma are specified on a case by case basis. To enable us to design and quote the most appropriate set up for your process please get in touch

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Comparison of SupaClean™ to Alternative Technologies

 

Feature

SupaClean™

Lenticular

Plate & Frame

Contained Operation

Yes

Limited

No

Operator Protection

Yes

Moderate

Low

Easy Catalyst Transport

Yes

Difficult

Difficult

Easy Cleaning

Yes

Moderate

Poor

Disposable

Yes

No

No

 
 
 
SupaClean Cross section II

Key Features

  •  Double Layer Flexible Containment bag for maximum security

  • Selection of bag materials (LPDE / FEP) to unsure fluid compatibility
  • Choice of inlet/outlet connections including sanitary Triclover
    Untitled design (6)
  • Secure Blanking Plugs to ensure containment during handling / transport to reprocessor 

    Untitled design (31)
  • The SupaClean system will accept any filter in the Amazon Filters range (e.g. SupaSpun / SupaPleat / SupaPore / SupaCarb)

    Email Headers (22)

 

In Focus: Catalyst Capture, Recovery and Reprocessing

A modified SupaClean™ featuring an extended bag maximises the quantity of catalyst that can be captured while the installed filters are selected to provide the required filtrate cleanliness for the next stage of API synthesis.  

Precious metal catalysts such as palladium are essential to pharmaceutical manufacturing but represent a significant cost, making efficient recovery critical for maximising value. SupaClean™ provides the containment and separation stage of the recovery process. As the reaction mixture passes through the system, catalyst particles are captured within the contained filter assembly while the product stream continues downstream for further processing. Once filtration is complete, the sealed assembly can be safely isolated and removed, eliminating direct handling of catalyst-containing filter elements.

The enclosed module can then be transferred to a specialist recovery partner for catalyst reclamation. By combining catalyst capture, containment and safe handling in a single solution, SupaClean™ simplifies catalyst recovery while supporting operator protection and process efficiency.

SupaClean Pharma Brochure schematic

 

FAQs

Our Filtration Solutions

SupaSpun II featured image SupaSpun II

Precision graded-density elements that build on Amazon Filters' long-proven absolute rated depth cartridge. They hold plenty of dirt at a low clean pressure drop, and swap straight in for Pall Profile II.

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supaporevp SupaPore VP

A pleated, high-surface-area PES membrane for a wide range of liquid processing. Naturally hydrophilic, it contains no wetting agents and holds very low extractables for clean, consistent filtrate.

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SupaPore VPH SupaPore VPH

Particularly suited to purified water systems, this pleated, high-surface-area PES membrane holds no wetting agents and very low extractables. It stands up to repeated steaming, autoclaving, and hot-water sanitisation.

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Supa-Pore-Group-2-cut-out-e1519301886448 SupaPore VPBA

Pairs a high-flow, asymmetric PES membrane with a built-in pre-filter layer, improving steam life and dirt-holding on heavily loaded pharmaceutical solutions. The second layer also wets more evenly for integrity testing.

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supaporepp SupaPore Nanofibre

A high positive charge draws negatively charged contaminants onto the media – endotoxins, bacteria, viruses, colloids, and metals. Its open structure keeps flow high, as an alternative to ultrafiltration.

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supacarbcp SupaCarb CP

Tuned for maximum decolourisation and organics reduction, our high-performance sintered block use acid-washed, steam-activated carbon that holds up in pharmaceutical API plants. Thermal welding replaces adhesives, so there's no bypass and nothing migrates into the product.

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SupaClean SupaClean Filter System

The SupaClean Filter System consists of a filter cartridge enclosed inside two sealed bags, ideal for hazardous materials and paint industries

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Capsule filters from Amazon Filters SupaPore THB

An expanded PTFE membrane over a large-bore core pushes high air and gas flow at low pressure drop, for fermenter off-gas, inlet air, and CO₂ lines. It won't wet out with water vapour, and steam-sterilises repeatedly.

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SupaPore TMB SupaPore TMB

Heat-resistant supports and hardware enable our SupaPore hydrophobic PTFE membrane to vent continuously at up to 90 °C. It keeps WFI tanks and fermenter inlet air sterile where the vent runs hot continuously, not just during sterilisation.

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71 series sanitary housings from Amazon Filters 71 Series

Hygienic tank vent housings with one combined inlet and outlet connection, mounting straight onto a sealed storage vessel. The seal-less Vee clamp releases by hand.

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72C series ASME BPE sanitary housings from Amazon Filters 72C Series ASME BPE

ASME BPE conforming housings that drain completely in the vertical position, for aseptic biopharmaceutical processing. Nothing collects in the base between batches.

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72C series in-line ASME BPE sanitary housings from Amazon Filters 72C Series In-Line ASME BPE

In-line housings with ASME BPE Tri-Clamp ferrules at 1, 1½, and 2 inches. They drop into existing pipework without a base mount and take up no floor space.

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76B series sanitary housings from Amazon Filters 76B Series

Crevice-free housings with a 0.4 µm Ra internal finish, in 316L or Alloy 22. The self-draining base cuts pressure loss, and they sanitise or steam sterilise in place.

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76C series ASME BPE sanitary housings from Amazon Filters 76C Series ASME BPE

Housings configured for low pressure drop in high flow gas, conforming to ASME BPE. Body lengths cover 5 to 30 inch cartridges, with Tri-Clamp ferrules at 1 and 1½ inches.

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Heating jackets for 50 & 70 series housings from Amazon Filters Heating Jackets for 50 & 70 Series Housings

Silicone or stainless steel jackets that wrap around 50 and 70 Series housings to stabilise temperature and prevent condensation on vent filters. Stainless steel carries an ATEX zone 1 and 2 rating.

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Certification & Approvals

All our products are manufactured in accordance with Quality Standard ISO 9001, Environment Standard ISO 14001 and Health & Safety Standard ISO 45001.

We are committed to manufacturing quality filtration solutions and adhere to the requirements of:

 

USP_04.17 ASME 1 FDA European Regulation (EC) Number 1935-2004-1 PED 2 PESR atex-certification-services-1

Let’s get started

We'll make sure you're getting the best out of your filtration for API manufacturing.