A team of researchers at South Dakota State University have developed a new drug delivery strategy designed specifically for medication that’s given to children in an oral suspension.
Manufacturing Chemist reported on the work of Om Perumal, who is leading the work looking at ways of making medication tastier and easier for children to swallow.
He has come up with a drug delivery system using the protein zein to encapsulate the medication. However, his team has also modified the nanoparticles of zein by coating them in milk proteins.
Mr Perumal explained that if you try to dissolve a drug that isn’t soluble, the result is a “thick, uninviting suspension”. He added that using an excipient with high alcohol content, as you would in adult medications, to dissolve the drug is “out of the question for young children”.
However, the milk-coated zein nanoparticles provide the best of both worlds. The zein nanoparticles themselves aren’t soluble, but the milk protein coating means they are more dispersible in water. In addition, the milk coating disguises the taste.
“We can put the nanoparticles into a liquid, chewable tablet or a capsule. We could even use them as food sprinkles,” Mr Perumal stated.
This isn’t the only new drug delivery system that’s been developed recently. Earlier this year, KUNC reported on work carried out by researchers at the University of California, San Diego, who have developed a tiny device to deliver drugs while reducing the presence of stomach acid.
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